March 19, 2021

UAMS’ Justin Leung, Ph.D., Receives $1.47 million Grant from National Cancer Institute to Study DNA Damage Regulation

Justin Leung, Ph.D., (front and center with his team), a researcher with the Winthrop P. Rockefeller Cancer Institute, has been awarded a $1.47 million National Cancer Institute grant to study DNA. Image by Evan D. Lewis

Justin Leung, Ph.D., (front and center with his team), a researcher with the Winthrop P. Rockefeller Cancer Institute, has been awarded a $1.47 million National Cancer Institute grant to study DNA. Image by Evan D. Lewis

By Linda Haymes

Leung’s project is a collaboration with Robert Eoff, Ph.D., a professor in the Department of Biochemistry and Molecular Biology in the UAMS College of Medicine. Both Leung and Eoff are researchers in the UAMS Winthrop P. Rockefeller Cancer Institute.

“Our work will potentially provide a fundamental understanding of the molecular mechanism of DNA damage regulation in our body and also reveal potential targets for cancer therapeutic development,” said Leung, an assistant professor in the UAMS College of Medicine Department of Radiation Oncology.

Work on the NCI grant, “Mechanistic Characterization of Cell Cycle-Dependent DNA Repair,” focuses on dissecting the molecular mechanism on cell cycle-regulated DNA repair, specifically during early DNA replication. Leung and Eoff hope to identify a key group of proteins known as a histone-mark reader that work together to protect our genetic material from DNA damage.

Read more HERE.