IL-6 variant is associated with metastasis in breast cancer patients.

Abana CO, Bingham BS, Cho JH, Graves AJ, Koyama T, Pilarski RT, Chakravarthy AB, Xia F.

PLoS One. 2017 Jul 21;12(7):e0181725. doi: 10.1371/journal.pone.0181725. eCollection 2017.


A phase I trial of concurrent sorafenib and stereotactic radiosurgery for patients with brain metastases.

Arneson K, Mondschein J, Stavas M, Cmelak AJ, Attia A, Horn L, Niermann K, Puzanov I, Chakravarthy AB, Xia F.

J Neurooncol. 2017 Jun;133(2):435-442. doi: 10.1007/s11060-017-2455-3. Epub 2017 May 9.


Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery.

Jiang J, Lu Y, Li Z, Li L, Niu D, Xu W, Liu J, Fu L, Zhou Z, Gu Y, Xia F.

Invest New Drugs. 2017 Jun;35(3):251-259. doi: 10.1007/s10637-016-0424-x. Epub 2017 Jan 23.


EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

Wu Y, Lee SH, Williamson EA, Reinert BL, Cho JH, Xia F, Jaiswal AS, Srinivasan G, Patel B, Brantley A, Zhou D, Shao L, Pathak R, Hauer-Jensen M, Singh S, Kong K, Wu X, Kim HS, Beissbarth T, Gaedcke J, Burma S, Nickoloff JA, Hromas RA.

PLoS Genet. 2015 Dec 18;11(12):e1005675. doi: 10.1371/journal.pgen.1005675. eCollection 2015 Dec.



Pyruvate Kinase Muscle Isoenzyme 2 (PKM2) Expression Is Associated with Overall Survival in Pancreatic Ductal Adenocarcinoma.

Lockney NA, Zhang M, Lu Y, Sopha SC, Washington MK, Merchant N, Zhao Z, Shyr Y, Chakravarthy AB, Xia F.

J Gastrointest Cancer. 2015 Dec;46(4):390-8. doi: 10.1007/s12029-015-9764-6.


Association between cytosolic expression of BRCA1 and metastatic risk in breast cancer.

Santivasi WL, Wang H, Wang T, Yang Q, Mo X, Brogi E, Haffty BG, Chakravarthy AB, Xia F.

Br J Cancer. 2015 Jul 28;113(3):453-9. doi: 10.1038/bjc.2015.208. Epub 2015 Jun 9.


Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair.

Hu Y, Wang C, Huang K, Xia F, Parvin JD, Mondal N.

PLoS One. 2014 Oct 22;9(10):e110522. doi: 10.1371/journal.pone.0110522. eCollection 2014.


Radiation necrosis mimicking rapid intracranial progression of melanoma metastasis in two patients treated with vemurafenib.

Liebner DA, Walston SA, Cavaliere R, Powers CJ, Sauvageau E, Lehman NL, Wayne Slone H, Xu-Welliver M, Xia F, Kendra KL.

Melanoma Res. 2014 Apr;24(2):172-6. doi: 10.1097/CMR.0000000000000044.


Ionizing radiation-induced DNA damage, response, and repair.

Santivasi WL, Xia F.

Antioxid Redox Signal. 2014 Jul 10;21(2):251-9. doi: 10.1089/ars.2013.5668. Epub 2014 Feb 3. Review.


Pattern of breast cancer susceptibility gene 1 expression is a potential prognostic biomarker in resectable pancreatic ductal adenocarcinoma.

Wang T, Wentz SC, Ausborn NL, Washington MK, Merchant N, Zhao Z, Shyr Y, Chakravarthy AB, Xia F.

Pancreas. 2013 Aug;42(6):977-82. doi: 10.1097/MPA.0b013e318287885c.


Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer.

Willers H, Azzoli CG, Santivasi WL, Xia F.

Cancer J. 2013 May-Jun;19(3):200-7. doi: 10.1097/PPO.0b013e318292e4e3. Review.


MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair.

Fang M, Xia F, Mahalingam M, Virbasius CM, Wajapeyee N, Green MR.

Mol Cell Biol. 2013 Jul;33(13):2635-47. doi: 10.1128/MCB.00167-13. Epub 2013 May 6.


53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19-9 in pancreatic adenocarcinoma.

Ausborn NL, Wang T, Wentz SC, Washington MK, Merchant NB, Zhao Z, Shyr Y, Chakravarthy AB, Xia F.

BMC Cancer. 2013 Mar 26;13:155. doi: 10.1186/1471-2407-13-155.


Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma.

Wentz SC, Zhao ZG, Shyr Y, Shi CJ, Merchant NB, Washington K, Xia F, Chakravarthy AB.

World J Gastrointest Oncol. 2012 Oct 15;4(10):207-15. doi: 10.4251/wjgo.v4.i10.207.


The role and clinical significance of DNA damage response and repair pathways in primary brain tumors.

Santivasi WL, Xia F.

Cell Biosci. 2013 Feb 6;3(1):10. doi: 10.1186/2045-3701-3-10.


BRCA1-Ku80 protein interaction enhances end-joining fidelity of chromosomal double-strand breaks in the G1 phase of the cell cycle.

Jiang G, Plo I, Wang T, Rahman M, Cho JH, Yang E, Lopez BS, Xia F.

J Biol Chem. 2013 Mar 29;288(13):8966-76. doi: 10.1074/jbc.M112.412650. Epub 2013 Jan 23.


Assaying DNA damage in hippocampal neurons using the comet assay.

Nowsheen S, Xia F, Yang ES.

J Vis Exp. 2012 Dec 19;(70):e50049. doi: 10.3791/50049.


Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-Ribose) polymerase inhibition.

Yang ES, Nowsheen S, Rahman MA, Cook RS, Xia F.

Cancer Res. 2012 Nov 1;72(21):5547-55. doi: 10.1158/0008-5472.CAN-12-0934. Epub 2012 Sep 7.