Dan Jia, D.D.S., Ph.D.

Research Assistant Professor

Phone: 501-526-7024

E-mail: JiaDan@uams.edu

Doctoral Degree: University of Toronto, Cell & Molecular Biology

Postdoctoral Training: University of Arkansas for Medical Sciences, College of Medicine, Division of Endocrinology

Research Interests: Cancer metastasis to bone, differentiation of osteoblast and osteoclast progenitors, bone metabolism

Selected Publications

Jia D, Heersche JN 2000 Insulin-like growth factor-1 and -2 stimulate osteoprogenitor proliferation and differentiation and adipocyte formation in cell populations derived from adult rat bone. Bone 27:785-794

Jia D, Heersche JN 2002 Expression of insulin-like growth factor system constituents in differentiating rat osteoblastic cell populations. Growth Horm IGF Res 12:399-410

O’Brien CA, Jia D, Plotkin LI, Bellido T, Powers CC, Stewart SA, Manolagas SC, Weinstein RS 2004 Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology 145:1835-1841

Weinstein RS, Jia D, Powers CC, Stewart SA, Jilka RL, Parfitt AM, Manolagas SC 2004 The skeletal effects of glucocorticoid excess override those of orchidectomy in mice. Endocrinology 145:1980-1987

Jia D, Heersche JN 2005 Pregnancy-associated plasma protein-A proteolytic activity in rat vertebral cell cultures: Stimulation by dexamethasone-a potential mechanism for glucocorticoid regulation of osteoprogenitor proliferation and differentiation. J Cell Physiol 204:848-858

Bellows CG, Jia D, Jia Y, Hassanloo A, Heersche JN 2006 Different effects of insulin and insulin-like growth factors I and II on osteoprogenitors and adipocyte progenitors in fetal rat bone cell populations. Calcif Tissue Int 79:57-65

Jia D, O’Brien CA, Stewart SA, Manolagas SC, Weinstein RS 2006 Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density. Endocrinology 147:5592-5599