Research Interests:

  • Molecular and physiological mechanisms of radiation and thermal sensitization
  • Modulation of tumor blood flow, angiogenesis and oxygenation
  • Biology and physiology of thermal therapy
  • Oxygen partial pressure as predictor of cancer treatment response

Clinic Research:

  • Interested in translational clinical studies to answer questions about the biological response of tumors to treatment with radiation or chemotherapy in order to move towards new standards of care

Education/Training:

  • Ph.D. Biophysical Sciences, 1998, University of Minnesota
  • B.A. Biology/Music, 1991, St. Olaf College, Northfield, MN

Publications:

  • Griffin RJ, Okajima K, Barrios B, Song CW: Mild temperature hyperthermia combined with carbogen breathing increases tumor pO2and radiosensitivity.  Cancer Res, 56:  5590-5593, 1996.
  •  Dings RPMD, Heun H, Griffioen AW, Mayo KM, Griffin RJ: Scheduling of radiation with angiogenesis inhibitors Avastin and Anginex improves therapeutic outcome via vessel normalization.  13(11):3395-402, Clin Cancer Res, 2007.
  •  Upreti M, Jamshidi-Parsian A, Apana S, Berridge M, Fologea DA, Koonce NA, Henry RL, Griffin RJ: Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature.   Journal of Mol Med, Apr;91(4):497-506, 2013.
  •  Koonce, NA, Raleigh, J, Dings RPM, Griffin RJ: Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia.  PLoS One, 10(8):e0135607, 2015.  PMID: 26308944
  •  Koonce, NA, Dings RPM, Quick, Griffin RJ: Combination of gold nanoparticle-conjugated TNF-a and radiation therapy results in a synergistic anti-tumor response. Int J Radiat Oncol Biol Phys.  93(3):588-96, 2015.  PMID:  26461001

 

More information on Dr. Griffin’s Lab and Lab research.